Neither the remote lock/unlock button or the interior lock/unlock button will work for the drivers door. All other doors do respond as normal. While researching this issue I've discovered that this is a very widespread issue on seemingly every model and year Toyota Highlander. Considering that each lock cycles with the press of the lock/unlock button, it is not logical that the vast, vast, majority of the non-responding locks is the one on the drivers door. When the doors are all locked, pressing the unlock button on the remote results in no response of any kind including the normal audible "beep" normally heard on all Toyotas. When pressing the lock button on the remote, the normal audible "beep" is heard but is followed almost instantly with another audible "beep" and the unlocking of the rest of the doors. All the doors except the drivers door will lock when pressing the lock button mounted on the door. The drivers door can be locked manually prior to closing the door and will remain locked. All the doors except the drivers door will unlock when the remote lock/unlock button is pushed. The key functions exactly as it should. It locks and unlocks all the doors including the drivers door. The problem does not seem to be purely mechanical such as linkage or a lose part. The problem is primarily electrical and seems to be related to the function of the switch when using the remote or console button.